Skip to main content

Main menu

  • Home
  • About the Journal
    • General Information
    • Scope
    • Editorial Board
    • Benefits of Publishing
    • Impact & Metrics
    • Advertising/Sponsorship
    • About the Biochemical Society
  • Current Issue
  • For Authors
    • Submit Your Paper
    • Submission Guidelines
    • Editorial Policy
    • Open Access Policy
    • Rights and Permissions
    • Biochemical Society Member Benefits
  • For Librarians
    • Subscriptions and Pricing
    • Open Access Policy
    • Clinical Science- Terms and Conditions of Usage
    • Register for Free Trial
  • For Readers
    • Rights and Permissions
    • Biochemical Society Member Benefits
    • Request a Free Trial
  • Collections
  • Help
    • Contact Us
  • Other Publications
    • Biochemical Journal
    • Clinical Science
    • Bioscience Reports
    • Neuronal Signaling
    • Biochemical Society Transactions
    • Essays in Biochemistry
    • Emerging Topics in Life Sciences
    • Biochemical Society Symposia
    • Cell Signalling Biology
    • Glossary of Biochemistry and Molecular Biology
    • The Biochemist
    • Biochemical Society

User menu

  • Log-in
  • Subscribe
  • Contact Us

Search

  • Advanced search
  • Other Publications
    • Biochemical Journal
    • Clinical Science
    • Bioscience Reports
    • Neuronal Signaling
    • Biochemical Society Transactions
    • Essays in Biochemistry
    • Emerging Topics in Life Sciences
    • Biochemical Society Symposia
    • Cell Signalling Biology
    • Glossary of Biochemistry and Molecular Biology
    • The Biochemist
    • Biochemical Society

Log-in

Sign-up for alerts  
  • My Cart
Clinical Science
Browse Archive
Advanced Search
  • Home
  • About the Journal
    • General Information
    • Scope
    • Editorial Board
    • Benefits of Publishing
    • Impact & Metrics
    • Advertising/Sponsorship
    • About the Biochemical Society
  • Current Issue
  • For Authors
    • Submit Your Paper
    • Submission Guidelines
    • Editorial Policy
    • Open Access Policy
    • Rights and Permissions
    • Biochemical Society Member Benefits
  • For Librarians
    • Subscriptions and Pricing
    • Open Access Policy
    • Clinical Science- Terms and Conditions of Usage
    • Register for Free Trial
  • For Readers
    • Rights and Permissions
    • Biochemical Society Member Benefits
    • Request a Free Trial
  • Collections
  • Help
    • Contact Us

Images under the category DNA methylation

  • Regulation of skeletal muscle mitochondrial function by nuclear receptors: implications for health and disease

    Joaquin Perez-Schindler, Andrew Philp
    Clinical Science Jul 14, 2015, 129 (7) 589-599; DOI: 10.1042/CS20150246
    Figure 1
    Figure 1
    Ligand-dependent regulation of NR activity In the absence of agonist (red circles) or the presence of an antagonist (black circles) NR activity is inhibited by the recruitment of transcriptional CoRs. These CoRs repress gene transcription, in part by decreasing and increasing the levels of histone acetylation (yellow circles) and DNA methylation (orange circles), respectively. In contrast, agonists induce an exchange of CoRs by transcriptional CoAs, which induce an open conformation of the chromatin by promoting the opposite epigenetic modifications. Consequently, the recruitment of CoAs increases the transcriptional activity of NRs and, thus, gene transcription. HRE, hormone response element.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Keywords:
    • DNA methylation
    • Nuclear receptor
    • Transcription
    • Epigenetics
  • Portland Press Homepage
  • Publish With Us
  • Advertising
  • Technical Support
  • Clinical Science
  • Biochemical Journal
  • Essays in Biochemistry
  • Biochemical Society Transactions
  • Biochemical Society Symposia
  • Bioscience Reports
  • Emerging Topics in Life Sciences
  • Neuronal Signaling
  • Cell Signalling Biology

Portland Press Limited
Charles Darwin House
12 Roger Street
Email: editorial@portlandpress.com

The Biochemical Society