Table 1 Studies including the TNF-superfamily triad members TRAIL/OPG/TWEAK as biomarkers and/or therapeutic targets in renal pathological conditions (reported on www.clinicaltrials.gov)
Disease pathological conditionsStudy typeTNF-superfamily memberIntervention(s)PhaseStatusStudy ID
CKDInt.OPG levels (biomarker)Plasma OPG level; FGF-23 level; vascular calcification scorenaRNCT02808572
CKDInt.OPG levels (biomarker)Plasma OPG level; FGF-23 level; vascular calcification scorenaRNCT02813642
Renal failure, haemodialysisInt.OPG levels (biomarker)Low molecular weigth heparin; unfractioned heparinnaUNCT00669721
Vitamin D Def., vascular calcification, ESRF, peritoneal dialysisInt.OPG levels (biomarker)Cholecalciferol; placeboIVANCT02598635
Chronic renal failureObs.OPG levels (biomarker)Identification of CV risk factors linked to renal failure progressionnaUnkNCT00608998
Renal transplantInt.OPG levels (biomarker)Zortress, everolimusnaWith.NCT01612299
Renal insufficiency, CKD, hyperphosphatemia bone diseasesInt.OPG levels (biomarker)Lanthanum carbonate; calcium carbonateIVENCT02237534
Kidney failure, chronic haemodialysisInt.OPG levels (biomarker)Apabetalone; placebosI-IIA*NCT03160430
Clear-cell, metastatic renal cell carcinoma, bone metastasesInt.OPG levels (biomarker)XOFIGO radium-223 dichlorideI-IIANCT02880943
Chronic kidney failure; inflammation vascular calcificationObs.OPG levels (biomarker)Vascular calcification’s risk factors in haemodialysis patientsnaCNCT00694824
Fabry diseaseInt.OPG levels (biomarker)RVX000222I-IIANCT03228940
Osteoporosis and CKDInt.OPG levels (biomarker)Denosumab; placeboIVA*NCT02792413
Renal cell carcinomaObs.OPG levels (biomarker)Assessment of bone biomarkers for TKI response in RCC with bone metastases, HRQoL and comparison of imaging techniquesnaTNCT02747173
Renal transplantation, immunosuppressionInt.OPG levels (biomarker)EverolimusIVUnkNCT01239472
Renal cancerInt.TRAIL (therapeutic)T-cells transduced with T-cell receptor recognizing TRAIL bound to the DR4I/IITNCT00923390
Diabetic patients with proteinuriaInt.TWEAK levels (biomarker)Calcium channel blocker amlodipineIVCNCT01738945
Diabetes, hypertension proteinuriaInt.TWEAK levels (biomarker)Renin angiotensin system blockage, calcium channel blocker amlodipine; valsartanIVCNCT00921570
Lupus nephritisInt.TWEAK (therapeutic)BIIB023 anti TWEAK monoclonal antibody; mycophenolate mofetil; oral corticosteroidsIITNCT01930890
Lupus nephritisInt.TWEAK (therapeutic)BIIB023 anti TWEAK monoclonal antibody; placebo; mycophenolate mofetil; oral corticosteroidsIITNCT01499355
Advanced solid tumoursInt.Anti Fn14 (therapeutic)PDL192 anti-TWEAKR monoclonal antibodyICNCT00738764
  • A: active; C: completed; T: terminated; Int: interventional; Obs: observational; With: withdrawn; R: recruiting; Unk: unknown; *: not recruiting yet; na.: not available (accessed November 2018).