Table 2 Top regulated canonical pathways and upstream regulators from Ingenuity analysis of the genes differentially expressed between female WT and KCNJ5 KO (−/−) adrenals
Canonical pathway nameP-valueOverlap
FXR/RXR activation1.58 × 10−1011.7% 16/137
L×R/R×R activation5.69 × 10−1011.7% 15/128
TR/R×R activation4.11 × 10−912.4% 13/105
Retinol biosynthesis3.11 × 10−818.4% 9/49
Acute phase response signalling2.13 × 10−78.2% 14/171
Upstream regulatorP-value of overlapPredicted activation
TO-901317 (L×R agonist)1.66 × 10−36Down in KO
PPARα2.89 × 10−36Down in KO
PPARγ1.15 × 10−35Down in KO
Rosiglitazone (PPARG agonist)3.16 × 10−33Down in KO
BSCL27.87 × 10−29-
  • Ranked by P-value.