Table 1 Protective effect of VPA and RGFP966 on diabetes-induced cardiac dysfunction
WT-VehWT-VPAWT-RGFP966OVE-VehOVE-VPAOVE-RGFP966
3 M
IVS;d (mm)0.63 ± 0.010.65 ± 0.030.63 ± 0.010.62 ± 0.030.65 ± 0.020.63 ± 0.02
LVID;d (mm)3.82 ± 0.023.86 ± 0.073.81 ± 0.024.10 ± 0.05*3.80 ± 0.023.81 ± 0.06
LVPW;d (mm)0.85 ± 0.030.87 ± 0.030.85 ± 0.030.80 ± 0.080.85 ± 0.030.85 ± 0.03
IVS;s (mm)1.05 ± 0.021.03 ± 0.051.00 ± 0.041.00 ± 0.061.06 ± 0.021.03 ± 0.02
LVID;s (mm)2.16 ± 0.022.15 ± 0.082.18 ± 0.042.70 ± 0.09*2.13 ± 0.032.15 ± 0.06
LVPW;s (mm)1.29 ± 0.031.30 ± 0.021.31 ± 0.021.27 ± 0.031.28 ± 0.031.28 ± 0.03
LV Vol;d (mm)62.69 ± 0.6264.34 ± 2.9062.34 ± 0.6274.30 ± 2.15*63.81 ± 0.8064.42 ± 2.10
LV Vol;s (mm)15.47 ± 0.3215.34 ± 1.415.81 ± 0.7627.06 ± 2.12*15.99 ± 0.6115.39 ± 1.08
%EF75.32 ± 0.2476.18 ± 1.5674.64 ± 1.0463.61 ± 2.24*75.74 ± 1.1075.35 ± 1.37
%FS43.43 ± 0.2344.28 ± 1.4342.82 ± 0.9334.18 ± 1.64*43.81 ± 1.0243.47 ± 1.24
LV mass (mg)97.73 ± 2.2699.62 ± 2.9196.56 ± 3.75104.78 ± 2.99*97.57 ± 2.5997.93 ± 3.40
6 M
IVS;d (mm)0.65 ± 0.020.65 ± 0.010.64 ± 0.010.64 ± 0.020.62 ± 0.020.64 ± 0.02
LVID;d (mm)3.82 ± 0.073.83 ± 0.053.77 ± 0.024.20 ± 0.12*4.02 ± 0.08*3.99 ± 0.03*
LVPW;d (mm)0.87 ± 0.020.86 ± 0.010.88 ± 0.010.91 ± 0.040.89 ± 0.060.89 ± 0.02
IVS;s (mm)1.00 ± 0.041.03 ± 0.021.00 ± 0.050.96 ± 0.060.95 ± 0.020.97 ± 0.04
LVID;s (mm)2.08 ± 0.002.08 ± 0.042.06 ± 0.022.96 ± 0.09*2.48 ± 0.04*2.43 ± 0.02*
LVPW;s (mm)1.30 ± 0.011.31 ± 0.011.30 ± 0.011.33 ± 0.031.31 ± 0.041.31 ± 0.06
LV Vol;d (mm)62.55 ± 2.9363.12 ± 2.3060.44 ± 0.6278.94 ± 5.40*70.85 ± 3.74*69.68 ± 1.01*
LV Vol;s (mm)14.03 ± 0.3013.95 ± 0.6013.72 ± 0.3534.36 ± 2.58*21.92 ± 2.58*20.87 ± 1.00*
%EF77.53 ± 1.1177.91 ± 0.1577.00 ± 0.3956.47 ± 1.75*71.93 ± 1.42*71.66 ± 2.09*
%FS45.50 ± 1.1245.86 ± 0.1345.20 ± 0.2729.25 ± 1.17*40.64 ± 1.23*40.40 ± 1.78*
LV mass (mg)99.98 ± 3.42100.68 ± 2.63101.52 ± 1.79127.37 ± 6.18*108.36 ± 1.30*110.45 ± 2.28*
  • IVS, interventricular septum; LVID;d, left ventricular internal diastolic diameter; LVID;s, left ventricular internal systolic diameter; LVPW, left ventricular posterior wall; LV vol;s, left ventricular end-systolic volume; LV vol;d, left ventricular end-diastolic volume; LV mass, left ventricular mass. Data are presented as means ± S.D.; *P<0.05 versus WT-Veh group; P<0.05 versus OVE-Veh group.