


Clinical Science Young Investigator Award winner

Paul Armstrong
Paul Armstrong completed his BSc degree with honours in Pharmacology at Edinburgh University in 2003. After taking a year out Paul moved to the William Harvey Research Institute (WHRI) in London, where he obtained his Master of Research (MRes) degree in 2005. Paul is currently in the final year of his PhD supervised by Professor Tim Warner at the WHRI. The aim of his research is to clarify further the relationships between the activation of the enzyme cyclo-oxygenase, and the associated production of thromboxane A2, and platelet aggregation and thrombosis. Importantly, there are widely reported theories regarding this relationship that underpin much of our thinking on anti-platelet therapy but the theories have not been rigorously tested. In his work he is using in vitro and in vivo pharmacological models, as well as studies on human volunteers' to explore these relationships. It is Paul's hope that his results will help us to understand better the protective effects of aspirin against thrombotic events, as well as shed light on aspirin-drug interactions and the phenomenon of aspirin resistance.
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