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Clinical Science (2008) Immediate Publication, doi:10.1042/CS20080078
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A single bout of whole-body resistance exercise augments basal VLDL-triacylglycerol removal from plasma in healthy untrained men
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Yiannis E Tsekouras, Faidon Magkos, Konstantinos I Prentzas, Konstantinos N Basioukas, Stergoula G Matsama, Amalia E Yanni, Stavros A Kavouras and Labros S Sidossis
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Nutrition and Dietetics, Harokopio University, Athens 17671, Greece. lsidossis@hua.gr
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A single bout of prolonged aerobic exercise lowers plasma triacylglycerol (TAG) concentrations the next day by increasing the efficiency of very low-density lipoprotein (VLDL)-TAG removal from the circulation. The effect of resistance exercise on VLDL-TAG metabolism is not known. Therefore, we evaluated VLDL-TAG kinetics by using stable isotope labeled tracers in 8 healthy untrained men (age: 25±1 years, body mass index: 24.5±0.6 kg/m2) in the post-absorptive state in the morning, on two separate occasions: once after performing a single 90-min bout of strenuous isokinetic resistance exercise (3 sets x 10 repetitions, 12 exercises at 80% of maximum peak torque production, with a 2-min rest interval between sets) on the preceding afternoon and once after an equivalent period of rest. Fasting plasma VLDL-TAG concentration the morning after exercise was significantly lower than the morning after rest (0.23±0.04 vs. 0.33±0.06 mmol/l, respectively, P=0.001). Hepatic VLDL-TAG secretion rate was not different (P=0.31), but plasma clearance rate of VLDL-TAG was significantly higher (by 26±8%) after exercise than rest (31±3 vs. 25±3 ml/min, respectively, P=0.004), and the mean residence time of VLDL-TAG in the circulation was significantly shorter (113±10 vs. 144±18 min, respectively, P=0.02). Fasting plasma free fatty acid and serum beta-hydroxybutyrate concentrations were both significantly higher after exercise than rest (P<0.05), whereas plasma glucose and serum insulin concentrations were not different (P>0.30). We conclude that, in healthy untrained men, a single bout of whole-body resistance exercise lowers fasting plasma VLDL-TAG concentration by augmenting VLDL-TAG removal from plasma. The effect appears to be qualitatively and quantitatively similar as that reported previously for aerobic exercise.
doi:10.1042/CS20080078
Received 6 March 2008/14 May 2008; Accepted 13 June 2008
Published as Immediate Publication 13 June 2008
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