News

Congratulations to Susan Morton (Australian National University): winner of the Young Investigator Award sponsored by Clinical Science at State of the Heart 2014, held in Adelaide, Australia.

Latest Collection

Kidney Health & Disease: A collection highlighting recent research papers and commissioned reviews on various aspects of kidney health and disease, including diabetic nephropathy, inflammatory kidney disease and chronic kidney disease.

New Call For Papers

We invite the submission of original papers to one of the following Calls for Papers by the deadline of 30 November 2015:

  1. Post-translational modifications of proteins: clinical implications
  2. Mitochondria: biology and pathology
  3. Obesity and co-morbidities

Meeting Highlights

ATP binding cassette transporters: from mechanism to organism (April 16-18 2015)
ABC transporters are one of the largest families of membrane proteins and their diverse functions underpin numerous key physiological processes, as well as being causative factors in a number of clinically relevant pathologies. This meeting will focus on the mechanisms of ABC transporters and how this is integral to their effects on organism and cell biology.
More information available from the Biochemical Society website here.

FEBS 2015: The Biochemical Basis of Life (July 4-9 2015)
FEBS 2015, the 40th FEBS Congress, will explore "The Biochemical Basis of Life". Topics covered include mechanisms of gene expression; membranes, receptors & bioenergetics; molecular neuroscience; and from chemical biology to molecular medicine.
More information available from the Biochemical Society website here.

SPOTLIGHT

Dionne E.M. Maessen, Coen D.A. Stehouwer and Casper G. Schalkwijk

The formation and accumulation of advanced glycation endproducts (AGEs) are related to diabetes and other age-related diseases. Methylglyoxal (MGO), a highly reactive dicarbonyl compound, is the major precursor in the formation of AGEs and is mainly formed as a byproduct of glycolysis.
Under physiological circumstances, MGO is detoxified by the glyoxalase system into D-lactate, with glyoxalase I as the key enzyme in the anti-glycation defence. New insights indicate that increased levels of MGO and the major MGO-derived AGE, methylglyoxal-derived hydroimidazolone 1, and dysfunctioning of the glyoxalase system are linked to several age-related health problems, such as diabetes, cardiovascular disease, cancer and disorders of the central nervous system.
This review from Casper Schalkwijk and colleagues, summarizes the mechanisms through which MGO is formed, its detoxification by the glyoxalase system and its effect on biochemical pathways in relation to the development of age-related diseases.
podcast
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