News

Congratulations to Susan Morton (Australian National University): winner of the Young Investigator Award sponsored by Clinical Science at State of the Heart 2014, held in Adelaide, Australia.

Latest Collection

Novel Models of Lung Disease: a Collection highlighting recent research papers and commissioned reviews on a range of animal models of lung disease.

New Call For Papers

We invite the submission of original papers to one of the following Calls for Papers by the deadline of 30 November 2015:

  1. Post-translational modifications of proteins: clinical implications
  2. Mitochondria: biology and pathology
  3. Obesity and co-morbidities

Meeting Highlights

Metabolic Drivers of Immunity
Obesity and nutrient excess are associated with inflammatory phenotypes and immune dysfunction. This joint Biochemical Society/British Society for Immunology conference will bring together key players to present emerging research on the importance of metabolism to normal maturation and differentiation of immune cells.
Abstract submission deadline extended to 28th Jan 2015 - submit here

Experimental Biology 2015
(28 March to 1 April 2015): come and visit the Biochemical Society booth (#515) and find out more about publishing in Clinical Science.

SPOTLIGHT

Javier Rodríguez-Carrio, Patricia López and Ana Suárez (University of Oviedo, Asturias, Spain)

Rheumatoid Arthritis (RA) is a chronic rheumatic condition hallmarked by joint inflammation and destruction by self-reactive immune responses. One of the main challenges in the clinical management of RA is early diagnosis, as there is a wide range of clinical presentations, and also the prediction of therapy outcome. There is a clear need for new biomarkers, and as genetic variants associated with the type I IFN pathway have been linked with RA development, as well as with clinical features and clinical outcome prediction, IFN may be appropriate.
In this review article, just published in the April issue of the journal, Rodríguez-Carrio, López and Suárez discuss the recent evidence supporting a role for type I IFNs in the immunopathology of RA, and analyse their possible role as biomarkers for disease management.
The authors also published their recent study describing how cell-derived micro particles in rheumatoid arthritis are associated with disease-specific features and traditional CVR factors, and impair endothelial functionality by promoting endothelial activation in vitro, available here.