News

Congratulations to Susan Morton (Australian National University): winner of the Young Investigator Award sponsored by Clinical Science at State of the Heart 2014, held in Adelaide, Australia.

Latest Collection

Novel Models of Lung Disease: a Collection highlighting recent research papers and commissioned reviews on a range of animal models of lung disease.

New Call For Papers

We invite the submission of original papers to one of the following Calls for Papers by the deadline of 30 November 2015:

  1. Post-translational modifications of proteins: clinical implications
  2. Mitochondria: biology and pathology
  3. Obesity and co-morbidities

Meeting Highlights

Metabolic Drivers of Immunity
Obesity and nutrient excess are associated with inflammatory phenotypes and immune dysfunction. This joint Biochemical Society/British Society for Immunology conference will bring together key players to present emerging research on the importance of metabolism to normal maturation and differentiation of immune cells.
More information available from the Biochemical Society website here.

Experimental Biology 2015
(28 March to 1 April 2015): come and visit the Biochemical Society booth (#515) and find out more about publishing in Clinical Science.

SPOTLIGHT

Andrew S. Brem and Rujun Gong (Brown University School of Medicine)

Mineralocorticoids such as aldosterone have a role in the development of renal fibrosis and glomerular disease.
'non-classical' mineralocorticoid receptors have been described in mesangial cells and podocytes within the glomerulus. Aldosterone induces excess production of reactive oxygen species (ROS) and oxidative stress in glomerular cells through activation of NADPH oxidase, and in mesangial cells has pro-apoptotic, mitogenic and pro-fibrogenic effects, all of which potentially promote active remodelling and expansion of the mesangium.
In their review, Andrew Brem and Rujun Gong describe this signalling in more detail and summarise the main mechanisms involved in the pathogenesis as well as the clinical implications of targeting aldosterone therapeutically.