2014 Impact Factor up to 5.629 - Clinical Science has received its highest ever Impact Factor of 5.629 in the 2013 Journal Citation Reports (Thomson Reuters 2014). A Top Quartile Journal in the Medicine (Research & Experimental) category, Clinical Science is now ranked 14 out of 122.

Latest Collection

Portland Press microRNA Collection, highlighting a selection of recent high-quality papers concerning various aspects in the field of miRNA that have been published in our family of journals (Biochemical Journal, Biochemical Society Transactions, Bioscience Reports and Clinical Science).

New Call For Papers

NADPH Oxidases in Health and Disease - we invite the submission of original papers by the deadline of 31 December 2014

Meeting Highlight

Congratulations to Dr Francisco Rios (University of Glasgow): winner of our Young Investigator Award at the recent HBPR2014 Scientific Sessions


Francesco Paneni, Sarah Costantino and Francesco Cosentino (Cardiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden)

Aging is the main risk factor and driver of incident cardiovascular disease and results in a progressive functional and structural decline of the vasculature. Currently, there is a need to focus on the fundamental processes of vascular aging to enable early diagnosis and prevention of cardiovascular disease. In the present review, the authors discuss advances in the pathophysiology of age-related vascular dysfunction including nitric oxide signalling, dysregulation of oxidant/inflammatory genes, epigenetic modifications and mechanisms of vascular calcification as well as insights into vascular repair, and highlight attractive molecular targets for the prevention of age-driven vascular disease.