News

2014 Impact Factor up to 5.629 - Clinical Science has received its highest ever Impact Factor of 5.629 in the 2013 Journal Citation Reports (Thomson Reuters 2014). A Top Quartile Journal in the Medicine (Research & Experimental) category, Clinical Science is now ranked 14 out of 122.

Latest Collection

Vasoactive Peptides in Health and Disease - This Collection contains Review Articles and Original Papers on the topic of vasoactive peptides with an introduction from the Guest Editor Dr Robson Santos. All of the papers are free until August 2014.

New Call For Papers

NADPH Oxidases in Health and Disease - we invite the submission of original papers by the deadline of 31 December 2014

Meeting Highlight

BSCR Autumn Meeting - Cardiovascular Signalling in Health and Disease, 8-9 September 2014, Reading, U.K. >> Meeting website

SPOTLIGHT

Maria Paz Ocaranza, Luis Michea, Mario Chiong, Carlos F. Lagos, Sergio Lavandero and Jorge E. Jalil (Pontificia Universidad Católica de Chile, Santiago, Chile)

Ang-(1-9) [angiotensin-(1-9)] is a novel vasoactive peptide and a new member of the renin-angiotensin system (RAS). In the present review, the authors summarize the biological effects of Ang-(1-9), providing new evidence of its cardiovascular-protective activity. They also discuss the potential mechanism by which this peptide prevents and ameliorates the cardiovascular damage induced by RAS activation.
This paper is freely available for 1 month as part of the Vasoactive Peptides in Health and Disease special online collection.
Latest Papers
Intrauterine inflammation gives rise to a reduction in the number and an increase in maturity of cardiac cells in the hearts of fetal lambs. This was accompanied by suppression of contractile function and enhanced vulnerability of the heart to reperfusion injury and stress.
Curcumin exerted inhibitory effects on nasopharyngeal carcinoma by inhibiting the expression of miR-125a-5p and subsequently enhancing the expression of TP53. Forced expression of miR-125a-5p enhanced the proliferation, migration and invasion of HONE1 cells.
Isometric-handgrip-exercise-induced local ischaemia in the normal limb facilitated collateral recruitment in acutely occluded vessels in patients with coronary artery disease. Ischaemic-handgrip-exercise-induced physical ischaemic training for 3 months facilitated myocardial collateral growth.
Increased sympathetic activation and oxidative stress/pro-inflammatory status cause lymphocytopenia by activating programmed lymphocyte death in patients with HF. Moreover, a low lymphocyte count correlates with reduced haemodynamics and aerobic capacity, which reflects poor generic/disease-specific QoL in the HF patients.
Targeting mitochondrial TSPO activity or maintaining its function could prove therapeutically useful in regressing atherosclerotic lesions, particularly since bioavailable TSPO ligands, without obvious side effects, are currently in development for other disease conditions.