Most Read Reviews

Which papers published in the last 3 years are being downloaded the most?
The number of downloads in the 12 months to the end of April 2012 are shown below

4718	TGF-beta/TGF-beta receptor system and its role in physiological and pathological conditions Juan Santibañez, Miguel Quintanilla and Carmelo Bernabeu (2011) 121, 233-251 doi:10.1042/CS20110086 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2626	A new look at the pathogenesis of asthma Stephen Holgate, Hasan Arshad, Graham Roberts, Peter Howarth, Philipp Thurner and Donna Davies (2010) 118, 439-450 doi:10.1042/CS20090474 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2418	Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition Mark Kirby, Denise Yu, Steve O'Connor and Mark Gorrell (2010) 118, 31-41 doi:10.1042/CS20090047 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2308	Healthy Aging and Disease: Role for Telomere Biology? Haidong Zhu, Matthew Belcher and Pim van der Harst (2011) 120, 427-440 doi:10.1042/CS20100385 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1858	Cellular and molecular mechanisms of metformin: an overview Benoit Viollet, Bruno Guigas, Nieves Sanz Garcia, Jocelyne Leclerc, Marc Foretz and Fabrizio Andreelli (2012) 122, 253-270 doi:10.1042/CS20110386 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1687	microRNA profiling in cancer Reinhold Munker and George Calin (2011) 121, 141-158 doi:10.1042/CS20110005 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1557	Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential Mark Hanke and Tammy Kielian (2011) 121, 367-387 doi:10.1042/CS20110164 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1395	Psoriasis: from pathogenesis to novel therapeutic approaches Giovanni Monteleone, Francesco Pallone, Thomas MacDonald, Sergio Chimenti and Antonio Costanzo (2011) 120, 1-11 doi:10.1042/CS20100163 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1395	IL-6/IL-6 receptor system and its role in physiological and pathological conditions Masahiko Mihara, Misato Hashizume, Hiroto Yoshida, Miho Suzuki and Masashi Shiina (2012) 122, 143-159 doi:10.1042/CS20110340 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1388	Regulation in Chronic Obstructive Pulmonary Disease: The Role of Regulatory T Cells and Th17 Cells Nina Lane, Richard Robins, Jonathan Corne and Lucy Fairclough (2010) 119, 75-86 doi:10.1042/CS20100033 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1332	Hypertension in Children – New Trends and Challenges Janusz Feber and Maheen Ahmed (2010) 119, 151-161 doi:10.1042/CS20090544 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1322	Role of Toll-like receptors in liver health and disease Ruth Broering, Mengji Lu and Joerg Schlaak (2011) 121, 415-426 doi:10.1042/CS20110065 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1287	RAGE biology, atherosclerosis and diabetes Drazenka Pongrac Barlovic, Aino Soro-Paavonen and Karin Jandeleit-Dahm (2011) 121, 43-55 doi:10.1042/CS20100501 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1286	Cellular and molecular effects of sirtuins in health and disease Yoshiyuki Horio, Takashi Hayashi, Atsushi Kuno and Risa Kunimoto (2011) 121, 191-203 doi:10.1042/CS20100587 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1267	Aging and vascular endothelial function in humans Douglas Seals, Kristen Jablonski and Anthony Donato (2011) 120, 357-375 doi:10.1042/CS20100476 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1232	Zinc-finger nucleases: new strategies to target the rat genome Aron Geurts and Carol Moreno (2010) 119, 303-311 doi:10.1042/CS20100201 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1195	Endoplasmic reticulum stress in disease: Mechanisms and therapeutic opportunities Toru Hosoi and Koichiro Ozawa (2010) 118, 19-29 doi:10.1042/CS20080680 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1159	AMPK-mediated regulation of transcription in skeletal muscle Sean McGee and Mark Hargreaves (2010) 118, 507-518 doi:10.1042/CS20090533 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1113	The forgotten face of regular physical exercise: a 'natural' anti-atherogenic activity Justyna Szostak and Pascal Laurant (2011) 121, 91-106 doi:10.1042/CS20100520 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1109	The circadian clock and metabolism Oren Froy (2011) 120, 65-72 doi:10.1042/CS20100327 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1105	Endothelial progenitor cells: novel biomarker and promising cell therapy for cardiovascular disease Shaundeep Sen, Stephen McDonald, Patrick Coates and Claudine Bonder (2011) 120, 263-283 doi:10.1042/CS20100429 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1088	Vascular calcification in chronic kidney disease Adrian Covic, Mehmet Kanbay, Luminita Voroneanu, Faruk Turgut, Dragomir Serban, Ionela Lacramioara Serban and David Goldsmith (2010) 119, 111-121 doi:10.1042/CS20090631 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1083	Angiotensin Receptor Blockers and Angiogenesis: Clinical and Experimental Evidence Lauren Willis, Azza El-Remessy, Somanath Shenoy, David Deremer and Susan Fagan (2011) 120, 307-319 doi:10.1042/CS20100389 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1029	Renin, (pro)renin and receptor: an update Genevieve Nguyen (2011) 120, 169-178 doi:10.1042/CS20100432 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1009	EMERGING ROLE OF HYDROGEN SULFIDE IN HEALTH AND DISEASE: critical appraisal of biomarkers and pharmacological tools Matthew Whiteman, Sophie Le Trionnaire, Mohit Chopra, Bridget Fox and Jacqueline Whatmore (2011) 121, 459-488 doi:10.1042/CS20110267 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1003	Cellular and molecular biology of Neisseria meningitidis colonisation and invasive disease Darryl Hill, Natalie Griffiths, Elena Borodina and Mumtaz Virji (2010) 118, 547-564 doi:10.1042/CS20090513 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
960	Role of Toll-like Receptors in Cardiovascular Diseases Jesus Vallejo (2011) 121, 1-10 doi:10.1042/CS20100539 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
930	IGF-1 and atherothrombosis Relevance to pathophysiology and therapy Elena Conti, Maria Beatrice Musumeci, Marco De Giusti, Eleonora Dito, Vittoria Mastromarino, Camillo Autore and Massimo Volpe (2011) 120, 377-402 doi:10.1042/CS20100400 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
906	Novel Noxes Homologues in the Vasculature: Focusing on Nox4 and Nox5 Augusto Montezano, Dylan Burger, Graziela Ceravolo, Hiba Yusuf, Maria Montero and Rhian Touyz (2011) 120, 131-141 doi:10.1042/CS20100384 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
887	Vitiligo, reactive oxygen species and T cells Steven Glassman (2011) 120, 99-120 doi:10.1042/CS20090603 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
871	Mast cells in health and disease Charlotte Weller, Sarah Collington, Timothy Williams and Jonathan Lamb (2011) 120, 473-484 doi:10.1042/CS20100459 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
834	IMPACT OF EXERCISE TRAINING ON ARTERIAL WALL THICKNESS IN HUMANS Dick Thijssen, N. Timothy Cable and Daniel Green (2012) 122, 311-322 doi:10.1042/CS20110469 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
830	Molecular Mechanisms of Cardiomyocyte Aging Anna Sheydina, Daniel Riordon and Kenneth Boheler (2011) 121, 315-329 doi:10.1042/CS20110115 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
790	Are Stem Cells a Cure for Diabetes? Michael McCall, Christian Toso, Emmanuel Baetge and AM Shapiro (2010) 118, 87-97 doi:10.1042/CS20090072 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
767	Atherosclerosis and sex hormones: current concepts Amparo Villablanca, Muthuvel Jayachandran and Carole Banka (2010) 119, 493-513 doi:10.1042/CS20100248 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
725	Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications Marcelo Roma, Flavia Toledo, Andrea Boaglio, Cecilia Basiglio, Fernando Crocenzi and Enrique Sánchez Pozzi (2011) 121, 523-544 doi:10.1042/CS20110184 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
717	Role of nuclear factor kappa B in cardiovascular health and disease Kim Van der Heiden, Simon Cuhlmann, Le Luong, Mustafa Zakkar and Paul Evans (2010) 118, 593-605 doi:10.1042/CS20090557 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
674	Diabetes impairs arteriogenesis in the peripheral circulation: review of molecular mechanisms Matthijs Ruiter, Jolanda van Golde, Nicolaas Schaper, Coen Stehouwer and Maya Huijberts (2010) 119, 225-238 doi:10.1042/CS20100082 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
633	Insulin resistance and hyperinsulinaemia in the development and progression of cancer Ian Godsland (2010) 118, 315-332 doi:10.1042/CS20090399 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
617	The vascular contribution to Alzheimer’s disease Robin Altman and John Rutledge (2010) 119, 407-421 doi:10.1042/CS20100094 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
617	Angiogenic growth factors in the diagnosis and prediction of preeclampsia Stefan Verlohren, Holger Stepan and Ralf Dechend (2011) 122, 43-52 doi:10.1042/CS20110097 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
615	Inflammatory cell recruitment in cardiovascular disease: murine models and potential clinical applications Eileen McNeill, Keith Channon and David Greaves (2010) 118, 641-655 doi:10.1042/CS20090488 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
576	Phosphate Toxicity: New Insights into an Old Problem M Razzaque (2011) 120, 91-97 doi:10.1042/CS20100377 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
575	Axl-dependent signalling: a clinical update Vyacheslav Korshunov (2012) 122, 361-368 doi:10.1042/CS20110411 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
572	Erythropoietin and the heart: facts and perspectives Vittoria Mastromarino, Massimo Volpe, Maria Beatrice Musumeci, Camillo Autore and Elena Conti (2011) 120, 51-63 doi:10.1042/CS20100305 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
557	Transient receptor potential channels and vascular function Scott Earley and Joseph Brayden (2010) 119, 19-36 doi:10.1042/CS20090641 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
553	DNA repair systems and pathogenesis of Mycobacterium tuberculosis: varying activities at different stages of infection Alina Gorna, Richard Bowater and Jaroslaw Dziadek (2010) 119, 187-202 doi:10.1042/CS20100041 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
543	Perivascular adipose tissue: more than just structural support Theodora Szasz and R Clinton Webb (2011) 122, 1-12 doi:10.1042/CS20110151 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
539	The role of nuclear factor kappa B in liver health and disease Stuart Robinson and Derek Mann (2010) 118, 691-705 doi:10.1042/CS20090549 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
491	Haem oxygenase-1 and cardiovascular disease: mechanisms and therapeutic potential Kim Chan, Martin Ng and Roland Stocker (2011) 120, 493-504 doi:10.1042/CS20100508 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF