Most Read papers

Which papers published in the last 3 years are being downloaded the most?
The number of downloads in the 12 months to the end of April 2012 are shown below

2077	Serum microRNA characterization identifies miR-885-5p as a potential marker for detecting liver pathologies Junhao Gui, Yaping Tian, Xinyu Wen, Wenhui Zhang, Pengjun Zhang, Jing Gao, Wei Run, Liyuan Tian, Xingwang Jia and Yanhong Gao (2011) 120, 183-193 doi:10.1042/CS20100297 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1177	Hypothesis Does activation of the FcγRIIa play a role in the pathogenesis of the acute lung injury / acute respiratory distress syndrome? Rafal Fudala, Agnieszka Krupa, Dorota Stankowska, Timothy Allen and Anna Kurdowska (2010) 118, 519-526 doi:10.1042/CS20090422 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1035	A translational study of circulating cell-free microRNA-1 in acute myocardial infarction Chunxiang Zhang, Yunhui Cheng, Ning Tan, Jian Yang, Xiaojun Liu, Xiaopei Cao, Pengcheng He, Xioli Dong and Shanshan Qin (2010) 119, 87-95 doi:10.1042/CS20090645 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
989	Comparative effects of telmisartan, sitagliptin and metformin alone or associated on obesity, insulin resistance, liver and pancreas remodelling in C57BL/6 mice fed a very high-fat diet Vanessa Souza-Mello, Bianca Gregorio, Fernando Cardoso-de-Lemos, Lais Carvalho, Marcia Aguila and Carlos Mandarim-de-Lacerda (2010) 119, 239-250 doi:10.1042/CS20100061 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
917	Hypothesis Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: The central role of ROS and nitric oxide Philip Newsholme, Paulo Homem de Bittencourt, Ciara O' Hagan, Giuseppe De Vito, Colin Murphy and Mauricio Krause (2010) 118, 341-349 doi:10.1042/CS20090433 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
853	Neurohumoral and haemodynamic profile in postural tachycardia and chronic fatigue syndromes Luis Okamoto, Satish Raj, Amanda Peltier, Alfredo Gamboa, Cyndya Shibao, Andre Diedrich, Bonnie Black, David Robertson and Italo Biaggioni (2012) 122, 183-192 doi:10.1042/CS20110200 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
841	Expression of microRNA-146a/b is associated with Toll-like receptor 4 signal in coronary artery disease: Effect of renin-angiotensin system blockade and statin on microRNA-146a/b and Toll-like receptor 4 levels Yuji Takahashi, Mamoru Satoh, Yoshitaka Minami, Tsuyoshi Tabuchi, Tomonori Itoh and Motoyuki Nakamura (2010) 119, 395-405 doi:10.1042/CS20100003 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
827	Regulation of IL-17 in chronic inflammation in the human lung Carol Pridgeon, Laurence Bugeon, Louise Donnelly, Ursula Straschil, Susan Tudhope, Jonathan Lamb, Peter Barnes, Margaret Dallman and Peter Fenwick (2011) 120, 515-524 doi:10.1042/CS20100417 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
811	Hypothesis Potential utility of small tyrosine kinase inhibitors in the treatment of diabetes Dariush Mokhtari and Nils Welsh (2010) 118, 241-247 doi:10.1042/CS20090348 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
759	The oncogenetic role of microRNA-31 as a potential biomarker in oesophageal squamous cell carcinoma Tengfei Zhang, Qiming Wang, Dan Zhao, Yaling Cui, Bangrong Cao, Liping Guo and Shih Hsin Lu (2011) 121, 437-447 doi:10.1042/CS20110207 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
666	Omega 3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia-hyperaminoacidaemia in healthy young and middle-aged men and women Gordon Smith, Philip Atherton, Dominic Reeds, B Mohammed, Debbie Rankin, Michael Rennie and Bettina Mittendorfer (2011) 121, 267-278 doi:10.1042/CS20100597 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
610	Accelerated Publication Eszopiclone increases the respiratory arousal threshold and lowers the apnea/hypopnea index in obstructive sleep apnea patients with low arousal threshold Danny Eckert, Robert Owens, Geoffrey Kehlmann, Andrew Wellman, Shilpa Rahangdale, Susie Yim-Yeh, David White and Atul Malhotra (2011) 120, 505-514 doi:10.1042/CS20100588 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
600	Gene expression profiling in whole blood of patients with coronary artery disease Chiara Taurino, William Miller, Martin McBride, John McClure, Raya Khanin, María Moreno, Jane Dymott, Christian Delles and Anna Dominiczak (2010) 119, 335-343 doi:10.1042/CS20100043 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
593	Sitagliptin prevents the development of metabolic and hormonal disturbances, increased β-cell apoptosis and liver steatosis induced by a fructose-rich diet in normal rats Bárbara Maiztegui, María Borelli, Viviana Madrid, Héctor Del Zotto, María Raschia, Flavio Francini, María Massa, Luis Flores, Oscar Rebolledo and Juan Gagliardino (2011) 120, 73-80 doi:10.1042/CS20100372 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
571	Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors Sanja Bosnyak, Emma Jones, Arthur Christopoulos, Marie-Isabel Aguilar, Walter Thomas and Robert Widdop (2011) 121, 297-303 doi:10.1042/CS20110036 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
565	Hypoxia aggravates nonalcoholic steatohepatitis in mice lacking hepatocellular PTEN Anne-Christine Piguet, Deborah Stroka, Arthur Zimmermann and Jean-François Dufour (2010) 118, 401-410 doi:10.1042/CS20090313 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
563	Mesenchymal stem cell injection ameliorates chronic renal failure in a rat model Sandra Villanueva, Ernesto Ewertz, Flavio Carrion, Andres Tapia, Cesar Vergara, Carlos Céspedes, Pablo Sáez, Patricia Luz, Carlos Irarrazabal, Juan Carreño, Fernando Figueroa and Carlos Vio (2011) 121, 489-499 doi:10.1042/CS20110108 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
562	Doxorubicin-induced cardiac dysfunction is attenuated by cyclosporine treatment in mice through improvements in mitochondrial bioenergetics Xavier Marechal, David Montaigne, Camille Marciniak, Philippe Marchetti, Jean Claude Beauvillain, Steve Lancel, Remi Neviere and Sidi Mohamed Hassoun (2011) 121, 405-413 doi:10.1042/CS20110069 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
548	Hypothesis The innate immune system and diabetes mellitus, the relevance of periodontitis? A hypothesis Martin Crook and Martin Lazenby (2010) 119, 423-429 doi:10.1042/CS20100098 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
507	Hypothesis Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring Eleanor Jarvie, Sylvie Hauguel-de Mouzon, Scott Nelson, Naveed Sattar, Patrick Catalano and Dilys Freeman (2010) 119, 123-129 doi:10.1042/CS20090640 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
460	Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE -/- mice Alan Daugherty, Debra Rateri, Israel Charo, A. Phillip Owens, Deborah Howatt and Lisa Cassis (2010) 118, 681-689 doi:10.1042/CS20090372 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
444	ACE2-angiotensin-(1-7)-Mas axis in renal ischemia/reperfusion injury in rats Kátia da Silveira, Kênia Pompermayer Bosco, Lúcio Diniz, Adriana Carmona, Giovanni Cassali, Oscar Bruna-Romero, Lirlândia de Sousa, Mauro Teixeira, Robson dos Santos, Ana Simões e Silva and Maria A Vieira (2010) 119, 385-394 doi:10.1042/CS20090554 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
443	Hypothesis Regulation of invasive growth: similar epigenetic mechanisms underpin tumour progression and implantation in human pregnancy Jo Perry, Roger Lins, Peter Lobie and Murray Mitchell (2010) 118, 451-457 doi:10.1042/CS20090503 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
436	Hypothesis Think the impossible: beta-blockers for treating asthma Brian Lipworth and Peter Williamson (2010) 118, 115-120 doi:10.1042/CS20090398 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
428	Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries Luciana Rossoni, Mark Wareing, Camilla Wenceslau, Mahmood Al-Abri, Christopher Cobb and Clare Austin (2011) 121, 449-458 doi:10.1042/CS20110259 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
401	Enhanced expression of pro-inflammatory mediators and liver X receptor-regulated lipogenic genes in nonalcoholic fatty liver disease and hepatitits C Elena Lima-Cabello, María Victoria García-Mediavilla, María Miquilena-Colina, Javier Vargas-Castrillón, Tamara Lozano-Rodríguez, Miguel Fernández-Bermejo, José Olcoz, Javier González-Gallego, Carmelo García-Monzón and Sonia Sánchez-Campos (2011) 120, 239-250 doi:10.1042/CS20100387 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
392	Angiotensin 1-7 infusion is associated with increased blood pressure and adverse cardiac remodelling in rats with subtotal nephrectomy Elena Velkoska, Rachael Dean, Karen Griggs, Luke Burchill and Louise Burrell (2011) 120, 335-345 doi:10.1042/CS20100280 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
380	Remote preconditioning provides potent cardioprotection via PI3k/Akt activation and is associated with nuclear accumulation of β-catenin Jing Li, Wanli Xuan, Ran Yan, Michael Tropak, Emilie Jean-St-Michel, Wenbin Liang, Rachel Gladstone, Peter Backx, Rajesh Kharbanda and Andrew Redington (2011) 120, 451-462 doi:10.1042/CS20100466 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
367	Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase Rocío López-Sepulveda, Manuel Gómez-Guzmán, Maria José Zarzuelo, Miguel Romero, Manuel Sánchez, Ana María Quintela, Pilar Galindo, Francisco O'Valle, Juan Tamargo, Francisco Pérez-Vizcaíno, Juan Duarte and Rosario Jiménez (2011) 120, 321-333 doi:10.1042/CS20100311 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
367	Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line Deirdre Keane, Hilton Takahashi, Shalinee Dhayal, Noel Morgan, Rui Curi and Philip Newsholme (2011) 120, 195-206 doi:10.1042/CS20100282 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
365	Influence of different breathing patterns on heart rate variability indices and reproducibility during experimental endotoxaemia in human subjects Matthijs Kox, Jan Pompe, Johannes van der Hoeven, Cornelia Hoedemaekers and Peter Pickkers (2011) 121, 215-222 doi:10.1042/CS20110027 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
359	Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in Apolipoprotein E-knockout mice Tim Schmidt, Eileen McNeill, Gillian Douglas, Mark Crabtree, Ashley Hale, Jeffrey Khoo, Alphonsus Cheng, Charles O'Neill, Keith Channon and Nicholas Alp (2010) 119, 131-142 doi:10.1042/CS20090559 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
356	Mesenchymal stromal cells improve renal injury in anti-Thy 1 nephritis by modulating inflammatory cytokines and scatter factors Teresa Rampino, Marilena Gregorini, Giulia Bedino, Giovanni Piotti, Elisa Gabanti, Adalberto Ibatici, Nadia Sessarego, Cristina Piacenza, Chiara Balenzano, Pasquale Esposito, Francesca Bosio, Grazia Soccio, Francesco Frassoni and Antonio Dal Canton (2011) 120, 25-36 doi:10.1042/CS20100147 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
351	Maternal protein restriction affects gene expression profiles in the kidney at weaning with implications to the regulation of renal function and lifespan Jian-Hua Chen, Jane Tarry-Adkins, Kieran Matharu, Giles Yeo and Susan Ozanne (2010) 119, 373-384 doi:10.1042/CS20100230 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
340	Invited Comment Hypoxia and non alcoholic fatty liver disease Christopher Byrne (2010) 118, 397-400 doi:10.1042/CS20090565 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
337	Toll Like Receptor 2 and 4 stimulation elicits an enhanced inflammatory response in human obese patients with atherosclerosis Vincent Scholtes, Dik Versteeg, Jean-Paul de Vries, Imo Hoefer, Arjan Schoneveld, Pieter Stella, Pieter Doevendans, Karlijn van Keulen, Dominique de Kleijn, Frans Moll and Gerard Pasterkamp (2011) 121, 205-214 doi:10.1042/CS20100601 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
334	High-sensitive Troponin T – a novel biomarker for prognosis and disease severity in patients with pulmonary hypertension Arthur Filusch, Evangelos Giannitsis, Hugo Katus and Franz Meyer (2010) 119, 207-213 doi:10.1042/CS20100014 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
333	Enhanced expression of receptor for advanced glycation end-products is associated with low circulating soluble isoforms of the receptor in Type 2 diabetes Kathryn Tan, Xystus Tam, Sammy Shiu, Lin Leng, Richard Bucala and John Betteridge (2011) 120, 81-89 doi:10.1042/CS20100256 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
332	Sex specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults Gary Pierce, Iratxe Eskurza, Ashley Walker, Tara Fay and Douglas Seals (2011) 120, 13-23 doi:10.1042/CS20100174 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
328	Impaired resistance artery function in patients with end stage renal disease Natallia Luksha, Leanid Luksha, Juan Carrero, Folke Hammarqvist, Peter Stenvinkel and Karolina Kublickiene (2011) 120, 525-536 doi:10.1042/CS20100277 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
325	Chronic fatigue syndrome: illness severity, sedentary lifestyle, blood volume and evidence of diminished cardiac function Barry Hurwitz, Virginia Coryell, Meela Parker, Pedro Martin, Arthur LaPerriere, Nancy Klimas, George Sfakianakis and Martin Bilsker (2010) 118, 125-135 doi:10.1042/CS20090055 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
323	Postprandial oxidative stress is modified by dietary fat: evidences from a human intervention study Pablo Perez-Martinez, Jose Garcia-Quintana, Elena Yubero-Serrano, Inmaculada Tasset-Cuevas, Isaac Tunez, Antonio Garcia-Rios, Javier Delgado-Lista, Carmen Marin, Francisco Perez-Jimenez, Helen Roche and Jose Lopez-Miranda (2010) 119, 251-261 doi:10.1042/CS20100015 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
318	Angiotensin II and ERK Pathway Mediate the Induction of Myocardin by Hypoxia in Cultured Rat Neonatal Cardiomyocytes Chiung-Zuan Chiu, Bao-Wei Wang, Tun-Hui Chung and Kou-Gi Shyu (2010) 119, 273-282 doi:10.1042/CS20100084 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
312	Administration of an acylated GLP-1 and GIP preparation provides added beneficial glucose-lowering and insulinotropic actions over single incretins in mice with type 2 diabetes and obesity Victor Gault, Barry Kerr, Patrick Harriott and PR Flatt (2011) 121, 107-117 doi:10.1042/CS20110006 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
307	Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions Samy Selim, Manjula Sunkara, Abdelghaffar Salous, Evgeny Berdyshev, Alison Bailey, Charles Campbell, Richard Charnigo, Andrew Morris, Susan Smyth and Steve Leung (2011) 121, 565-572 doi:10.1042/CS20110236 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
307	Activation of peripheral blood mononuclear cells and extracellular matrix and inflammatory gene profile in acute myocardial infarction Lu Fang, Xiao-Jun Du, Xiao-Ming Gao and Anthony Dart (2010) 119, 175-183 doi:10.1042/CS20100011 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
303	Hepatic stellate cells stimulate HCC cell migration via Laminin-5 production Angela Santamato, Emilia Fransvea, Francesco Dituri, Alessandra Caligiuri, Michele Quaranta, Tomoaki Niimi, Massimo Pinzani, Salvatore Antonaci and Gianluigi Giannelli (2011) 121, 159-168 doi:10.1042/CS20110002 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
301	Increased plasma concentrations of anterior gradient 2 protein are positively associated with ovarian cancer Tracey Edgell, Dong Barraclough, Antonio Rajic, Janu Dhulia, Kate Lewis, Jane Armes, Roger Barraclough, Philip Rudland, Gregory Rice and Dominic Autelitano (2010) 118, 717-725 doi:10.1042/CS20090537 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
301	Significance of serum adiponectin levels in patients with chronic liver disease Maria Balmer, Jeannine Joneli, Alain Schoepfer, Felix Stickel, Wolfgang Thormann and Jean-Francois Dufour (2010) 119, 431-436 doi:10.1042/CS20100008 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
298	Methionine and protein metabolism in non alcoholic steatohepatitis: evidence for lower rate of transmethylation of methionine Satish Kalhan, John Edmison, Susan Marczewski, Lourdes Gruca, Carole Bennett, Clarita Duenas, Rocio Lopez and Srinivasan Dasarathy (2011) 121, 179-189 doi:10.1042/CS20110060 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF