A series of Review Articles specially commissioned by Professor Rhian Touyz to mark her appointment as Editor-in-Chief of Clinical Science, along with Original Papers published on the topic

(Pro)renin and its receptors: pathophysiological implications
Wendy W. Batenburg and A. H. Jan Danser

Regulation of angiotensin II receptors beyond the classical pathway
Masatsugu Horiuchi, Jun Iwanami and Masaki Mogi

The renin–angiotensin system, bone marrow and progenitor cells
Matej Durik, Bruno Sevá Pessôa and Anton J. M. Roks

Update on new aspects of the renin–angiotensin system in liver disease: clinical implications and new therapeutic options
Josephine A. Grace, Chandana B. Herath, Kai Yan Mak, Louise M. Burrell and Peter W. Angus

The intracrine renin–angiotensin system
Rajesh Kumar, Candice M. Thomas, Qian Chen Yong, Wen Chen and Kenneth M. Baker

Angiotensin-(1-7) in kidney disease: a review of the controversies
Danielle Zimmerman and Kevin D. Burns

Renin–angiotensin system blockade: a novel therapeutic approach in chronic obstructive pulmonary disease
Dinesh Shrikrishna, Ronan Astin, Paul R. Kemp and Nicholas S. Hopkinson

Involvement of the renin–angiotensin system in abdominal and thoracic aortic aneurysms
Hong Lu, Debra L. Rateri, Dennis Bruemmer, Lisa A. Cassis and Alan Daugherty

Angiotensin II AT1 receptor blockers as treatments for inflammatory brain disorders
Juan M. Saavedra

The ACE2 gene: its potential as a functional candidate for cardiovascular disease
Louise M. Burrell, Stephen B. Harrap, Elena Velkoska and Sheila K. Patel

Local bone marrow renin–angiotensin system in primitive, definitive and neoplastic haematopoiesis
Ibrahim C. Haznedaroglu and Yavuz Beyazit

Angiotensin-(1–7): beyond the cardio-renal actions
Danielle G. Passos Silva, Thiago Verano Braga and Robson A. S. Santos

Renin inhibition in the treatment of diabetic kidney disease
Radko Komers

Reactive oxygen species, Nox and angiotensin II in angiogenesis: implications for retinopathy
Jennifer L. Wilkinson Berka, Indrajeetsinh Rana, Roksana Armani and Alex Agrotis

The direct renin inhibitor aliskiren improves vascular remodeling in transgenic rats harboring human renin and angiotensinogen genes
Carmine Savoia, Emanuele Arrabito, Rosa Parente, Lidia Sada, Luca Madaro, Carmine Nicoletti, Luigi Zezza, Alessandro Alonzo, Speranza Rubattu, Serena Michelini, Dominik N Muller and Massimo Volpe

Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor
Candice M. Thomas, Qian Chen Yong, Rachid Seqqat, Niketa Chandel, David L. Feldman, Kenneth M. Baker and Rajesh Kumar

Angiotensin II potentiates α-adrenergic vasoconstriction in the elderly
Zachary Barrett O'Keefe, Melissa A. H. Witman, John Mcdaniel, Anette S. Fjeldstad‖, Joel D. Trinity, Stephen J. Ives, Jamie D. Conklin, Van Reese, Sean Runnels, David E. Morgan, Mikael Sander, Russell S. Richardson and D. Walter Wray

Protective role of AT2 and B1 receptors in kinin B2-receptor-knockout mice with myocardial infarction
Jiang Xu, Oscar A. Carretero, Liping Zhu, Edward G. Shesely, Nour Eddine Rhaleb, Xiangguo Dai, Luchen Wang, James J. Yang and Xiao Ping Yang

Do high doses of AT1-receptor blockers attenuate central sympathetic outflow in humans with chronic heart failure?
Marcel Ruzicka, John S. Floras, Andrew J. G. McReynolds, Elizabeth Coletta, Haissam Haddad, Ross Davies and Frans H. H. Leenen

Combination renin–angiotensin system blockade and angiotensin-converting enzyme 2 in experimental myocardial infarction: implications for future therapeutic directions
Luke J. Burchill, Elena Velkoska, Rachael G. Dean, Karen Griggs, Sheila K. Patel and Louise M. Burrell

Interaction of diabetes and ACE2 in the pathogenesis of cardiovascular disease in experimental diabetes
Chris Tikellis, Raelene Pickering, Despina Tsorotes, Xiao Jun Du, Helen Kiriazis, Thu Phuc Nguyen Huu, Geoffrey A. Head, Mark E. Cooper and Merlin C. Thomas

Effect of angiotensin receptor blockade on insulin sensitivity and endothelial function in abdominally obese hypertensive patients with impaired fasting glucose
Todd S. Perlstein, Robert R. Henry, Kieren J. Mather, Michael R. Rickels, Nicola I. Abate, Scott M. Grundy, Yabing Mai, Jeanine B. Albu, Jennifer B. Marks, James L. Pool and Mark A. Creager

Mechanism of the inhibitory effect of atorvastatin on leptin expression induced by angiotensin II in cultured human coronary artery smooth muscle cells
Kou Gi Shyu, Shih Chung Chen, Bao Wei Wang, Wen Pin Cheng and Huei Fong Hung

Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension
Jan Neckář, Libor Kopkan, Zuzana Husková, František Kolář, František Papoušek, Herbert J. Kramer, Sung Hee Hwang, Bruce D. Hammock, John D. Imig, Jiří Malý, Ivan Netuka, Bohuslav Ošťádal and Luděk Červenka

Exaggerated natriuresis during clamping of systemic NO supply in healthy young men
Jane A. Simonsen, Mona S. Rasmussen, Werner Vach, Poul F. Høilund Carlsen and Peter Bie

Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors
Sanja Bosnyak, Emma S. Jones, Arthur Christopoulos, Marie Isabel Aguilar, Walter G. Thomas and Robert E. Widdop

Angiotensin-(1‑7) infusion is associated with increased blood pressure and adverse cardiac remodelling in rats with subtotal nephrectomy
Elena Velkoska, Rachael G. Dean, Karen Griggs, Luke Burchill and Louise M. Burrell

ACE2‑angiotensin-(1‑7)‑Mas axis in renal ischaemia/reperfusion injury in rats
Kátia D. da Silveira, Kênia S. Pompermayer Bosco, Lúcio R. L. Diniz, Adriana K. Carmona, Giovanni D. Cassali, Oscar Bruna Romero, Lirlândia P. de Sousa, Mauro M. Teixeira, Robson A. S. Santos, Ana C. Simões e Silva and Maria A. Ribeiro Vieira

Angiotensin II and the ERK pathway mediate the induction of myocardin by hypoxia in cultured rat neonatal cardiomyocytes
Chiung Zuan Chiu, Bao Wei Wang, Tun Hui Chung and Kou Gi Shyu

Inhibition of the renin‑angiotensin system prevents seizures in a rat model of epilepsy
Marilia G.A.G. Pereira, Christiane Becari, José A.C. Oliveira, Maria Cristina O. Salgado, Norberto Garcia Cairasco and Claudio M. Costa Neto

Expression of miR-146a/b is associated with the Toll-like receptor 4 signal in coronary artery disease: effect of renin‑angiotensin system blockade and statins on miRNA-146a/b and Toll-like receptor 4 levels
Yuji Takahashi, Mamoru Satoh, Yoshitaka Minami, Tsuyoshi Tabuchi, Tomonori Itoh and Motoyuki Nakamura

Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice
Alan Daugherty, Debra L. Rateri, Israel F. Charo, A. Phillip Owens III, Deborah A. Howatt and Lisa A. Cassis

Reduction in renal ACE2 expression in subtotal nephrectomy in rats is ameliorated with ACE inhibition
Elena Velkoska, Rachael G. Dean, Luke Burchill, Vicki Levidiotis and Louise M. Burrell