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ISI Journal Citation Reports® (2009)
Impact factor: 3.982 5-Year Impact Factor: 3.890
Immediacy index: 1.239 Cited half-life: 9.2 years


Editor-in-Chief: R. Clinton Webb (Augusta) supported by an international editorial board, with editorial offices in the UK and USA


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In addition to being a potent vasoconstrictor, endothelin (ET)-1 has been reported to have other deleterious properties, including effects on inflammation, fibrosis and hyperplasia. In this Review, Marc Iglarz and Martine Clozel focus on the function of the ET axis as an autocrine/paracrine system in normal and pathological situations, and discuss the interactions with other tissue hormonal systems, the long-term consequences of ET receptor blockade and the potential benefits in clinical practice, particularly in end-organ damage.

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