ISI Journal Citation Reports® (2009)
Impact factor: 3.982	5-Year Impact Factor: 3.890
Immediacy index: 1.239	Cited half-life: 9.2 years

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Take a look at our spotlight on Clinical Science Editor-in-Chief, R. Clinton Webb. Clinton talks about his life and work and the benefits of publishing in Clinical Science.

At the heart of tissue: endothelin system and end-organ damage

In addition to being a potent vasoconstrictor, endothelin (ET)-1 has been reported to have other deleterious properties, including effects on inflammation, fibrosis and hyperplasia. In this Review, Marc Iglarz and Martine Clozel focus on the function of the ET axis as an autocrine/paracrine system in normal and pathological situations, and discuss the interactions with other tissue hormonal systems, the long-term consequences of ET receptor blockade and the potential benefits in clinical practice, particularly in end-organ damage.

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