Aim. Adipose tissue (AT) inflammation leads to increased free fatty acids efflux and ectopic fat deposition, but whether AT dysfunction drives to selective fat accumulation in specific sites remains unknown. Aim of this study was to investigate the correlation between AT dysfunction, hepatic/pancreatic fat fraction (HFF, PFF) and the associated metabolic phenotype in patients with type 2 diabetes (T2D).
Methods. Sixty-five consecutive T2D patients were recruited at the Diabetes Centre of Sapienza University, Rome, Italy. Study population underwent clinical examination and blood sampling for routine biochemistry and calculation of insulin secretion (HOMA-β%) and insulin-resistance (HOMA-IR, ADIPO-IR) indexes. Subcutaneous (SAT) and visceral (VAT) AT area, HFF and PFF were determined by magnetic resonance.
Results. 55.4% of T2D patients had NAFLD; they were significantly younger and more insulin-resistant than non-NAFLD subjects. ADIPO-IR was the main determinant of HFF independent of age, sex, HOMA-IR, VAT, SAT and predicted severe NAFLD with AUROC=0.796 (C.I.95%:0.65-0.94, p=0.001). PFF was independently associated with increased total adiposity but did not correlate with AT dysfunction, insulin resistance and secretion or NAFLD.
Conclusions. The ADIPO-IR index was capable of predicting NAFLD independent of all confounders whereas it did not seem to be related to intrapancreatic fat deposition; unlike HFF, higher PFF was not associated with relevant alterations in the metabolic profile. In conclusion, the presence and severity of AT dysfunction may drive ectopic fat accumulation towards specific targets, such as VAT and liver; therefore, evaluation of AT dysfunction may contribute to identify different risk profiles among T2D patients.
- white adipose tissue
- ©2016 The Author(s)
This is an Accepted Manuscript; not the final Version of Record. Archiving permitted only in line with the archiving policy of Portland Press Limited. All other rights reserved.