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The E1 α and β Subunits of the Pyruvate Dehydrogenase Complex are M2‘d’ and M2‘e’ Autoantigens in Primary Biliary Cirrhosis

Shelley P. M. Fussey, Margaret F. Bassendine, Dorothy Fittes, Ian B. Turner, Oliver F. W. James, Stephen J. Yeaman
Clinical Science Oct 01, 1989, 77 (4) 365-368; DOI: 10.1042/cs0770365
Shelley P. M. Fussey
Department of Biochemistry and Genetics, Newcastle upon Tyne, U.K.
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Margaret F. Bassendine
Department of Medicine, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, U.K.
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Dorothy Fittes
Department of Biochemistry and Genetics, Newcastle upon Tyne, U.K.
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Ian B. Turner
Department of Medicine, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, U.K.
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Oliver F. W. James
Department of Medicine, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, U.K.
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Stephen J. Yeaman
Department of Biochemistry and Genetics, Newcastle upon Tyne, U.K.
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Abstract

1. Sera from 76 patients with primary biliary cirrhosis (PBC) and 66 control subjects (53 with chronic liver disease and 13 healthy normal women) were immunoblotted against purified E1 component of bovine pyruvate dehydrogenase complex (PDC) and bacterial PDC.

2. Thirty-one out of seventy-six (41%) sera from PBC patients showed a positive response to bovine E1α, and five of these 31 (7% of total) reacted with bovine E1β. None of the control sera reacted with bovine E1 α or β.

3. None of the PBC sera that recognized bovine E1 subunits reacted with bacterial PDC E1.

4. In the PBC patients there was no correlation between presence of antibodies to E1α and β subunits and histological stage of the disease.

5. Our data demonstrate that the E1α and β components of mammalian PDC are the M2‘d’ and ‘e’ mitochondrial autoantigens, respectively.

  • antimitochondrial antibodies
  • autoimmunity
  • primary biliary cirrhosis
  • pyruvate dehydrogenase complex
  • © 1989 The Biochemical Society and the Medical Research Society
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October 1989

Volume: 77 Issue: 4

Clinical Science: 77 (4)
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The E1 α and β Subunits of the Pyruvate Dehydrogenase Complex are M2‘d’ and M2‘e’ Autoantigens in Primary Biliary Cirrhosis
Shelley P. M. Fussey, Margaret F. Bassendine, Dorothy Fittes, Ian B. Turner, Oliver F. W. James, Stephen J. Yeaman
Clinical Science Oct 1989, 77 (4) 365-368; DOI: 10.1042/cs0770365
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The E1 α and β Subunits of the Pyruvate Dehydrogenase Complex are M2‘d’ and M2‘e’ Autoantigens in Primary Biliary Cirrhosis
Shelley P. M. Fussey, Margaret F. Bassendine, Dorothy Fittes, Ian B. Turner, Oliver F. W. James, Stephen J. Yeaman
Clinical Science Oct 1989, 77 (4) 365-368; DOI: 10.1042/cs0770365

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Keywords

antimitochondrial antibodies
autoimmunity
primary biliary cirrhosis
pyruvate dehydrogenase complex

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