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Abnormal sodium handling occurs in the isolated perfused kidney of the nephrotic rat

John D. Firth, Anthony E. G. Raine, John G. G. Ledingham
Clinical Science Apr 01, 1989, 76 (4) 387-395; DOI: 10.1042/cs0760387
John D. Firth
Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, U.K.
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Anthony E. G. Raine
Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, U.K.
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John G. G. Ledingham
Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, U.K.
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Abstract

1. In order to examine the handling of sodium by the nephrotic kidney when separated from the immediate influences of renal nerves and humoral factors, kidneys were taken from nephrotic rats (puromycin aminonucleo-side) and studied over a range of perfusion pressures using the isolated perfused kidney technique.

2. When perfused with medium containing 6.7 g/dl albumin, the nephrotic kidneys performed differently from controls with a reduction in sodium excretion at all pressures [(mean ± sem) 1.14 ± 0.43 vs 4.20 ± 0.69 μmol/min at 105 mmHg (14 kPa); 6.32 ± 1.56 vs 44.60 ± 5.30 μmol/min at 150 mmHg (20 kPa)]. Renal vascular resistance, inulin clearance, fractional sodium excretion and fractional lithium excretion were also reduced.

3. When kidneys were perfused without oncotic agent these differences between nephrotic and control kidneys remained. Perfusion with medium containing 10 g/dl albumin, designed to prevent glomerular filtration, abolished the difference in vascular resistance between the two groups. Captopril had no effect on the sodium retention or vascular resistance of nephrotic kidneys.

4. It was concluded that (a) the isolated nephrotic kidney demonstrates increased avidity for sodium, (b) the abnormality of sodium handling is not dependent on the presence of altered oncotic forces, and (c) the alteration in vascular resistance is conditional upon glomerular filtration.

  • isolated perfused kidney
  • nephrotic syndrome
  • puromycin aminonucleoside
  • © 1989 The Biochemical Society and the Medical Research Society
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April 1989

Volume: 76 Issue: 4

Clinical Science: 76 (4)
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Abnormal sodium handling occurs in the isolated perfused kidney of the nephrotic rat
John D. Firth, Anthony E. G. Raine, John G. G. Ledingham
Clinical Science Apr 1989, 76 (4) 387-395; DOI: 10.1042/cs0760387
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Abnormal sodium handling occurs in the isolated perfused kidney of the nephrotic rat
John D. Firth, Anthony E. G. Raine, John G. G. Ledingham
Clinical Science Apr 1989, 76 (4) 387-395; DOI: 10.1042/cs0760387

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Keywords

isolated perfused kidney
nephrotic syndrome
puromycin aminonucleoside

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