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Dissociation between Central and Peripheral Noradrenergic Activity in Essential Hypertension

C. R. Lake, R. J. Polinsky, H.-G. Gullner, M. H. Ebert, M. G. Ziegler, F. C. Bartter, I. J. Kopin
Clinical Science Jan 01, 1980, 59 (s6) 229s-233s; DOI: 10.1042/cs059229s
C. R. Lake
Uniformed Services Medical School, Bethesda, Maryland NIMH, Bethesda, Maryland
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R. J. Polinsky
NIMH, Bethesda, Maryland
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H.-G. Gullner
VA Hospital and UTHSC, San Antonio, Texas
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M. H. Ebert
NIMH, Bethesda, Maryland
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M. G. Ziegler
UTMB, Galveston, Texas, U.S.A.
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F. C. Bartter
VA Hospital and UTHSC, San Antonio, Texas
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I. J. Kopin
NIMH, Bethesda, Maryland
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Abstract

1. Eleven patients with essential hypertension and nine healthy normotensive volunteer subjects, all without a neurological disorder, had blood drawn and cerebrospinal fluid sampled for analysis of noradrenaline (NA).

2. Cerebrospinal fluid NA levels were elevated (P<0.01) in the hypertensive patients but plasma levels of NA were similar between groups.

3. The results suggest there is noradrenergic hyperactivity in the central nervous system which is not reflected in abnormal peripheral sympathetic nervous system function in this group of patients.

  • cerebrospinal fluid
  • essential hypertension
  • norepinephrine
  • noradrenaline
  • sympathetic nervous system
  • © 1980 The Biochemical Society and the Medical Research Society
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January 1980

Volume: 59 Issue: s6

Clinical Science: 59 (s6)
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Dissociation between Central and Peripheral Noradrenergic Activity in Essential Hypertension
C. R. Lake, R. J. Polinsky, H.-G. Gullner, M. H. Ebert, M. G. Ziegler, F. C. Bartter, I. J. Kopin
Clinical Science Jan 1980, 59 (s6) 229s-233s; DOI: 10.1042/cs059229s
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Dissociation between Central and Peripheral Noradrenergic Activity in Essential Hypertension
C. R. Lake, R. J. Polinsky, H.-G. Gullner, M. H. Ebert, M. G. Ziegler, F. C. Bartter, I. J. Kopin
Clinical Science Jan 1980, 59 (s6) 229s-233s; DOI: 10.1042/cs059229s

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Keywords

cerebrospinal fluid
essential hypertension
norepinephrine
noradrenaline
sympathetic nervous system

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