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Growth Hormone Secretion in Hypertensive Patients: Evidence for a Derangement in Central Adrenergic Function

C. Barbieri, C. Ferrari, R. Caldara, G. Curtarelli
Clinical Science Feb 01, 1980, 58 (2) 135-138; DOI: 10.1042/cs0580135
C. Barbieri
Second Department of Medicine, Fatebenefratelll Hospital, Milan, Italy
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C. Ferrari
Second Department of Medicine, Fatebenefratelll Hospital, Milan, Italy
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R. Caldara
Second Department of Medicine, Fatebenefratelll Hospital, Milan, Italy
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G. Curtarelli
Second Department of Medicine, Fatebenefratelll Hospital, Milan, Italy
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Abstract

1. In an attempt to test the hypothesis of a derangement in central catecholaminergic function in hypertensive patients, the serum growth hormone and prolactin responses to the α-adrenergic agonist clonidine (0·15 mg infused intravenously) and to l-dopa administration (500 mg orally) were evaluated in 15 hypertensive and 15 normotensive subjects matched for sex, age and body weight.

2. Whereas l-dopa elicited a growth hormone response of similar magnitude in both groups, clonidine infusion induced a significant increase in serum growth hormone in normotensive, but not in hypertensive, subjects.

3. Prolactin levels were equally suppressed by l-dopa and did not change after clonidine in either group.

4. The present study adds neuroendocrine evidence to the concept of a derangement in central α-adrenergic function in human hypertension.

  • central adrenergic function
  • clonidine
  • l-dopa
  • growth hormone
  • hypertensive patients
  • prolactin
  • © 1980 The Biochemical Society and the Medical Research Society
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February 1980

Volume: 58 Issue: 2

Clinical Science: 58 (2)
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Growth Hormone Secretion in Hypertensive Patients: Evidence for a Derangement in Central Adrenergic Function
C. Barbieri, C. Ferrari, R. Caldara, G. Curtarelli
Clinical Science Feb 1980, 58 (2) 135-138; DOI: 10.1042/cs0580135
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Growth Hormone Secretion in Hypertensive Patients: Evidence for a Derangement in Central Adrenergic Function
C. Barbieri, C. Ferrari, R. Caldara, G. Curtarelli
Clinical Science Feb 1980, 58 (2) 135-138; DOI: 10.1042/cs0580135

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Keywords

central adrenergic function
clonidine
l-dopa
growth hormone
hypertensive patients
prolactin

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