Abstract
Blood-based bioenergetic profiling has promising applications as a minimally invasive biomarker of systemic bioenergetic capacity. In the present study, we examined peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a cohort of African Americans with long-standing Type 2 diabetes. Key parameters of PBMC respiration were correlated with white matter, gray matter, and total intracranial volumes. Our analyses indicate that these relationships are primarily driven by the relationship of systemic bioenergetic capacity with total intracranial volume, suggesting that systemic differences in mitochondrial function may play a role in overall brain morphology.
- bioenergetics
- diabetes
- mitochondria
- neuroimaging
Abbreviations
- 3T MRI,
- 3 Tesla Magnetic Resonance Imaging;
- AA-DHS Mind,
- African American–Diabetic Heart Study Mind;
- BMI,
- basal metabolic rate;
- ETS,
- maximal ETC mediated respiratory system activity;
- FAO,
- fatty acid oxidation;
- FCCP,
- carbonyl cyanide-4- (trifluoromethoxy) phenylhydrazone;
- MRI,
- magnetic resonance imaging;
- MoCA,
- Montreal Cognitive Assessment;
- OCR,
- oxygen consumption rate;
- PBMC,
- peripheral blood mononuclear cell;
- T2DM,
- Type 2 diabetes mellitus;
- WFSM,
- Wake Forest School of Medicine
- © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
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