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Research article

Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes

Gargi Mahapatra, S. Carrie Smith, Timothy M. Hughes, Benjamin Wagner, Joseph A. Maldjian, Barry I. Freedman, Anthony J. A. Molina
Clinical Science Dec 05, 2018, 132 (23) 2509-2518; DOI: 10.1042/CS20180690
Gargi Mahapatra
Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University Health Sciences, Winston-Salem, NC 27157, U.S.A.
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S. Carrie Smith
Centers for Genomics and Personalized Medicine Research and Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, U.S.A.
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Timothy M. Hughes
Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University Health Sciences, Winston-Salem, NC 27157, U.S.A.
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Benjamin Wagner
Department of Radiology, Advanced Neuroscience Imaging Research (ANSIR) Laboratory, University of Texas Southwestern Medical Center, Dallas, TX, U.S.A.
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Joseph A. Maldjian
Department of Radiology, Advanced Neuroscience Imaging Research (ANSIR) Laboratory, University of Texas Southwestern Medical Center, Dallas, TX, U.S.A.
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Barry I. Freedman
Centers for Genomics and Personalized Medicine Research and Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, U.S.A.Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, U.S.A.
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Anthony J. A. Molina
Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University Health Sciences, Winston-Salem, NC 27157, U.S.A.Department of Medicine, Division of Geriatrics and Gerontology, University of California San Diego School of Medicine, La Jolla, CA 92093, U.S.A.
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  • http://orcid.org/0000-0002-5786-4622
  • For correspondence: ajmolina@ucsd.edu
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Abstract

Blood-based bioenergetic profiling has promising applications as a minimally invasive biomarker of systemic bioenergetic capacity. In the present study, we examined peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a cohort of African Americans with long-standing Type 2 diabetes. Key parameters of PBMC respiration were correlated with white matter, gray matter, and total intracranial volumes. Our analyses indicate that these relationships are primarily driven by the relationship of systemic bioenergetic capacity with total intracranial volume, suggesting that systemic differences in mitochondrial function may play a role in overall brain morphology.

  • bioenergetics
  • diabetes
  • mitochondria
  • neuroimaging
  • Abbreviations

    3T MRI,
    3 Tesla Magnetic Resonance Imaging;
    AA-DHS Mind,
    African American–Diabetic Heart Study Mind;
    BMI,
    basal metabolic rate;
    ETS,
    maximal ETC mediated respiratory system activity;
    FAO,
    fatty acid oxidation;
    FCCP,
    carbonyl cyanide-4- (trifluoromethoxy) phenylhydrazone;
    MRI,
    magnetic resonance imaging;
    MoCA,
    Montreal Cognitive Assessment;
    OCR,
    oxygen consumption rate;
    PBMC,
    peripheral blood mononuclear cell;
    T2DM,
    Type 2 diabetes mellitus;
    WFSM,
    Wake Forest School of Medicine
    • © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
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    December 2018

    Volume: 132 Issue: 23

    Clinical Science: 132 (23)
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    Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes
    Gargi Mahapatra, S. Carrie Smith, Timothy M. Hughes, Benjamin Wagner, Joseph A. Maldjian, Barry I. Freedman, Anthony J. A. Molina
    Clinical Science Dec 2018, 132 (23) 2509-2518; DOI: 10.1042/CS20180690
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    Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes
    Gargi Mahapatra, S. Carrie Smith, Timothy M. Hughes, Benjamin Wagner, Joseph A. Maldjian, Barry I. Freedman, Anthony J. A. Molina
    Clinical Science Dec 2018, 132 (23) 2509-2518; DOI: 10.1042/CS20180690

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    Keywords

    bioenergetics
    diabetes
    mitochondria
    neuroimaging

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