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Review article

Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia

Jessica Duncombe, Akihiro Kitamura, Yoshiki Hase, Masafumi Ihara, Raj N. Kalaria, Karen Horsburgh
Clinical Science Sep 28, 2017, 131 (19) 2451-2468; DOI: 10.1042/CS20160727
Jessica Duncombe
Centre for Neuroregeneration, University of Edinburgh, Edinburgh, U.K.
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Akihiro Kitamura
Centre for Neuroregeneration, University of Edinburgh, Edinburgh, U.K.
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Yoshiki Hase
National Cerebral and Cardiovascular Center, Osaka, JapanInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, U.K.
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Masafumi Ihara
National Cerebral and Cardiovascular Center, Osaka, JapanInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, U.K.
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Raj N. Kalaria
National Cerebral and Cardiovascular Center, Osaka, JapanInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, U.K.
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Karen Horsburgh
National Cerebral and Cardiovascular Center, Osaka, JapanInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, U.K.
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  • For correspondence: karen.horsburgh@ed.ac.uk
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Article Information

vol. 131 no. 19 2451-2468

DOI 
https://doi.org/10.1042/CS20160727
PubMed 
28963120

Print ISSN 
0143-5221
Online ISSN 
1470-8736

Copyright & Usage 
© 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society

History 
  • Published online September 28, 2017.

Author Information

  1. Jessica Duncombe1*,
  2. Akihiro Kitamura1*,
  3. Yoshiki Hase2,3*,
  4. Masafumi Ihara2,3,
  5. Raj N. Kalaria2,3 and
  6. Karen Horsburgh2,3⇑
  1. 1Centre for Neuroregeneration, University of Edinburgh, Edinburgh, U.K.
  2. 2National Cerebral and Cardiovascular Center, Osaka, Japan
  3. 3Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, U.K.
  1. Correspondence:
    Karen Horsburgh (karen.horsburgh{at}ed.ac.uk)
  1. ↵* These authors contributed equally to this work.

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Article usage

Article usage: September 2017 to March 2018

AbstractFullPdf
Sep 20174386
Oct 2017597105188
Nov 2017112197142
Dec 20171819094
Jan 201843585119
Feb 20181894355
Mar 20182032639
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October 2017

Volume: 131 Issue: 19

Clinical Science: 131 (19)
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Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia
Jessica Duncombe, Akihiro Kitamura, Yoshiki Hase, Masafumi Ihara, Raj N. Kalaria, Karen Horsburgh
Clinical Science Oct 2017, 131 (19) 2451-2468; DOI: 10.1042/CS20160727
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Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia
Jessica Duncombe, Akihiro Kitamura, Yoshiki Hase, Masafumi Ihara, Raj N. Kalaria, Karen Horsburgh
Clinical Science Oct 2017, 131 (19) 2451-2468; DOI: 10.1042/CS20160727

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  • Article
    • Abstract
    • Introduction
    • What have we learned from the rodent models of chronic cerebral hypoperfusion?
    • Neuropathological changes
    • Interplay between cerebral hypoperfusion and comorbidities
    • Preclinical investigation of drug targets
    • Important considerations of the models: how can we close the gap between rodent models of chronic cerebral hypoperfusion and human VCID?
    • Funding
    • Competing interests
    • Acknowledgments
    • References
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Keywords

Alzheimers disease
cerebral hypoperfusion
cognitive impairment
dementia
model organisms
small vessel disease

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