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vol. 131 no. 19 2451-2468
PubMed
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© 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
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- Published online September 28, 2017.
Author Information
- Jessica Duncombe1*,
- Akihiro Kitamura1*,
- Yoshiki Hase2,3*,
- Masafumi Ihara2,3,
- Raj N. Kalaria2,3 and
- Karen Horsburgh2,3⇑
- 1Centre for Neuroregeneration, University of Edinburgh, Edinburgh, U.K.
- 2National Cerebral and Cardiovascular Center, Osaka, Japan
- 3Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, U.K.
- Correspondence:
Karen Horsburgh (karen.horsburgh{at}ed.ac.uk)
↵* These authors contributed equally to this work.
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October 2017
Volume: 131 Issue: 19
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Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia
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- Article
- Abstract
- Introduction
- What have we learned from the rodent models of chronic cerebral hypoperfusion?
- Neuropathological changes
- Interplay between cerebral hypoperfusion and comorbidities
- Preclinical investigation of drug targets
- Important considerations of the models: how can we close the gap between rodent models of chronic cerebral hypoperfusion and human VCID?
- Funding
- Competing interests
- Acknowledgments
- References
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