H2S (hydrogen sulfide), viewed with dread for more than 300 years, is rapidly becoming a ubiquitously present and physiologically relevant signalling molecule. Knowledge of the production and metabolism of H2S has spurred interest in delineating its functions both in physiology and pathophysiology of disease. Although its role in blood pressure regulation and interaction with NO is controversial, H2S, through its anti-apoptotic, anti-inflammatory and antioxidant effects, has demonstrated significant cardioprotection. As a result, a number of sulfide-donor drugs, including garlic-derived polysulfides, are currently being designed and investigated for the treatment of cardiovascular conditions, specifically myocardial ischaemic disease. However, huge gaps remain in our knowledge about this gasotransmitter. Only by additional studies will we understand more about the role of this intriguing molecule in the treatment of cardiovascular disease.
- cardiovascular disease
- drug therapy
- hydrogen sulfide (H2S)
- nitric oxide (NO)
Abbreviations: BP, blood pressure; CBS, cystathionine β-synthase; CSE, cystathionine γ-lyase; DADS, diallyl disulfide; I/R, ischaemia/reperfusion; IPC, ischaemic preconditioning; LDL, low-density lipoprotein; LPS, lipopolysaccharide; MAP, mean arterial pressure; MAPK, mitogen-activated protein kinase; 3-MST, 3-mercaptopyruvate sulfurtransferase; NOS, NO synthase; eNOS, endothelial NOS; Nrf, nuclear factor-erythroid 2-related factor; NSAID, non-steroidal anti-inflammatory drug; PKC, protein kinase C; SAC, S-allylcysteine; SNP, sodium nitroprusside; SPRC, S-propargylcysteine
- © The Authors Journal compilation © 2011 Biochemical Society